Product ID:BUPIVACAINE HYDROCHLORIDE INJECTION,USP
MSDS Date:12/13/1991
FSC:6505
NIIN:00-138-7345
MSDS Number: BWMCH

Emergency Phone: 708-937-6100

Info Phone: 708-937-6100/800-222-6883

Cage: 60060

Telephone: 847-935-7177

Cage: 60060

BUPIVACAINE HYDROCHLORIDE

CAS: 18910-40-7

LD50 LC50 Mixture:LD50 (SCU, RAT) IS 48 MG/KG.
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:HIGHLY TOXIC NO HAZARD FOR INTACT
VIALS. THIS DRUG PRODUCES NUMBNESS BY BLOCKING NERVE
CONDUCTION.THIS ACTION MAY ADVERSELY AFFECT THE CNS AND HEART.MAY
BE DERMALLY ABSORBED IN HARMFUL AMOUNTS.
Explanation of Carcinogenicity:THERE ARE NO INGREDIENTS ABOVE 0.1%
WHICH ARE IDENTIFIED AS CARCINOGENS BY NTP,IARC OR OSHA.
Effects of Overexposure:SYSTEMIC TOXICITY:NUMBNESS,EXCITATION/
DEPRESSION,RESTLESSNESS,ANXIETY,DIZZINESS,BLURRED VISION,TREMORS,
CONVULSIONS,HYPOTENSION,SLOWED PULSE,HEART ARRYTHMIA,"RINGING
EARS".
Medical Cond Aggravated by Exposure:PERSONS WITH PRE-EXISTING CNS OR
HEART AILMENTS OR SENSITIVITY TO AMIDE TYPE LOCAL ANESTHETICS MAY
BE AT INCREASED RISK FROM EXPOSURE.

First Aid:SKIN:REMOVE CONTAMINATED CLOTHING;WASH WITH SOAP AND WATER.IF
TOXICITY SYMPTOMS OCCUR,GET MEDICAL ASSISTNCE.EYES:FLUSH WITH WATER
FOR 15 MINUTES.INHAL:REMOVE TO FRESH AIR.GIVE OXYGEN OR ARTIFICIAL
RES PIRATION IF NEEDED.INGEST:DO NOT INDUCEVOMITING.GET PROMPT
QUALIFIED MEDICAL ATTENTION.NO ANTIDOTE;TREAT SYMPTOMATICALLY AND
SUPPORTIVELY

Flash Point:NONE
Extinguishing Media:USE MEDIA APPROPRIATE FOR SURROUNDING FIRE.
Fire Fighting Procedures:USE A SELF-CONTAINED BREATHING APPARATUS AND
FULL PROTECTIVE EQUIPMENT.
Unusual Fire/Explosion Hazard:NONE SPECIFIED BY MANUFACTURER.

Spill Release Procedures:USE PROPER PROTECTIVE EQUIPMENT.SOAK UP WITH
NON-COMBUSTIBLE INERT ADSORBANT(EG.CLAY);PLACE COLLECTED MATERIAL
IN AN APPROPRIATE CONTAINER FOR DISPOSAL;CLEAN SPILL AREA TO REMOVE
SLIPPERINESS.
Neutralizing Agent:NOT APPLICABLE.

Handling and Storage Precautions:STORE IN A COOL,DRY,WELL-VENTILATED
PLACE. KEEP CONTAINER CLOSED WHEN NOT IN USE.PROTECT FROM FREEZING.
Other Precautions:FOLLOW LABEL DIRECTIONS.

Respiratory Protection:NOT NEEDED IN NORMAL SERVICE.
Ventilation:NOT NEEDED IN NORMAL SERVICE.
Protective Gloves:NOT NEEDED IN NORMAL SERVICE.
Eye Protection:NOT NEEDED IN NORMAL SERVICE.
Other Protective Equipment:PROVIDE A LOCAL EYE WASH STATION.
Work Hygienic Practices:USE REASONABLE CARE IN HANDLING THIS
PRODUCT.WASH HANDS AFTER USE AND BEFORE EATING.
Supplemental Safety and Health
NONE

HCC:N1
Boiling Pt:B.P. Text:212F,100C
Melt/Freeze Pt:M.P/F.P Text:32.0F,0.0C
Spec Gravity:1
pH:4-6.5
Solubility in Water:COMPLETE
Appearance and Odor:LIQUID;CLEAR.ODOR NOT REPORTED.
Percent Volatiles by Volume:NEGLIG

Stability Indicator/Materials to Avoid:YES
NONE SPECIFIED BY MANUFACTURER.
Stability Condition to Avoid:NONE SPECIFIED BY MANUFACTURER.
Hazardous Decomposition Products:NONE SPECIFIED BY MANUFACTURER.

Waste Disposal Methods:DISPOSE OF IN ACCORDANCE WITH FEDERAL,STATE AND
LOCAL REGULATIONS.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.